STP research projects

STP — Haematology and Transfusion Science

“Immuno-flowFISH”: Diagnostic assessment of structural chromosomal abnormalities in phenotyped chronic lymphocytic leukaemia cells with del(17p) by imaging flow cytometry

STP — Respitory and Sleep Sciences

A comparative assessment of the relationship between measurements made in an incremental shuttle walk test and an incremental cycle ergometry test in patients with idiopathic pulmonary fibrosis

STP — Vascular Science

A feasibility study for ultrasound-guided fistulaplasty for failing arteriovenous fistulae for haemodialysis.

STP — Image Ionising Radiation

A Quantitative Comparison of PET/CT and SPECT/CT for post Y-90 SIRT Therapy

STP — Cardiac Science

A retrospective analysis investigating the correlation between patients with diastolic dysfunction and diabetes mellitus within a local population.

STP — Audiology

Accuracy of hearing aid ‘match to target’ at fitting (before and after real-ear adjustment) and follow-up.

STP — Clinical Measurement and Development

An expert system for clinical gait analysis using an opinion-evidence model

STP — Genetics

Angelman Syndrome: Mosaicism or multi-locus imprinting defect?

STP — Histocompatibility and Immunogenetics

Anti-idiotypic antibodies in human leukocyte antigen (HLA) antibody-incompatible renal transplantation

STP — Cardiac Science

Assessing the impact of Cardiac Resynchronisation Therapy upon patients with Heart Failure in a real world UK setting; can routinely obtained markers provide a novel method of predicting response?

STP — Haematology and Transfusion Science

Characterisation of Intestinal Intraepithelial Lymphocytes by Flow Cytometry in Post-transplant Patients

STP — Clinical Bioinformatics - Physical Sciences

Classification of contributory factors in free-text NHS patient safety incident reports

STP — Image Ionising Radiation

Compartmental model for 223Ra-Dichloride in Patients with metastatic bone disease from castration-resistant prostate cancer

STP — Vascular Science

Contrast enhanced ultrasound (CEUS) in the assessment of foot perfusion: a feasibility study in a normal population

STP — Clinical Biochemistry

Development and Evaluation of Inductively-Coupled Plasma Mass Spectrometry Methods for the Quantitation of Selenium in Erythrocytes, and Other Trace Elements in Patient Samples

STP — Reproductive Science

Development of a clinic-specific, morphokinetic algorithm capable of predicting the implantation potential of human embryos

STP — Genetics

Development of a fluorescent multiplex RT-PCR assay for detection of fusion-gene transcripts

STP — Clinical Biochemistry

Development of assays for functional and direct markers of vitamin B1 and magnesium status in chronic alcoholic patients

STP — Radiotherapy Physics

Development of Cardiac Avoidance Treatment Planning for Non-Small Cell Lung Cancer Patients

STP — Imaging Non-Ionising Radiation

Diagnosing MS using Central Veins at Clinically Relevant Image Resolutions

STP — Clinical Microbiology

Diarrhoea in the community – Defining the burden of undiagnosed pathogenic E. coli.

STP — Imaging Non-Ionising Radiation

Diffusion-Weighted Magnetic Resonance Imaging of the Parotid glands in healthy volunteers before and after a gustatory stimulation to quantify relative function

STP — Radiotherapy Physics

Does the lung density around the tumour affect the ability to achieve the required dose constraints for lung Stereotactic Ablative Body Radiotherapy (SABR) treatments?

STP — Radiotherapy Physics

Dosimetric effects of residual, system-related, geometric distortion on MR-only radiotherapy planning for treatment of endometrial cancer using VMAT

STP — Clinical Bioinformatics - Genomics

Evaluation of in silico tools for pathogenicity prediction of missense variants in the diagnostic laboratory

STP — Radiotherapy Physics

Evaluation of the difference between dose-to-water and dose-to-medium for stereotactic ablative radiotherapy (SAbR) with the Acuros XB algorithm focusing on lung and bone using clinical plans.

STP — Genetics

Implementation of a workflow for the detection and validation of low level somatic BRCA1/BRCA2 variants for the clinical management of high grade serous ovarian cancer patients

STP — Radiotherapy Physics

Indirect MRI planning for prostate external beam radiotherapy without the use of implanted ducials

STP — Reproductive Science

KIDScore (D3, D5) as a predictor of pregnancy outcome, compared with conventional morphology grading of embryos

STP — Cardiac Science

Left ventricular scar predicts remodeling in patients undergoing cardiac resynchronisation therapy – a retrospective analysis from a large tertiary centre

STP — Audiology

Nystagmus duration after caloric irrigations

STP — Radiotherapy Physics

Quantification of changes to dose distribution caused by positional corrections from verification image matching to rectal and anal cancer patients during IMRT treatment

STP — Image Ionising Radiation

Quantitative Evaluation of Beta-Amyloid Brain PET Imaging in Dementia: A comparison between both Hermes BRASS and Siemens Syngo.VIA Amyloid Plaque Quantification with the clinical report

STP — Imaging Non-Ionising Radiation

Real-Data Reconstruction to Remove Rician Bias from Diffusional Kurtosis Imaging of the Prostate

STP — Genetics

The Characterisation of Mitochondrial DNA Rearrangements using the Illumina MiSeq and Oxford Nanopore Technologies MinION

STP — Cardiac Science

The Incidence and Clinical Relevance of Device-detected Subclinical Atrial Fibrillation in the Relation to Stroke.

STP — Respitory and Sleep Sciences

The Lung Clearance Index in Adults with Connective Tissue Disease. A Pilot Study in Patients with Rheumatoid Arthritis and Mixed Connective Tissue Disease.

STP — Neurophysiology

The perception and reality of sleep quality and diagnostic yield in sleep telemetry services: a feasibility study

STP — Neurophysiology

The relationship between Near-Infrared Spectroscopy (NIRS), Somatosensory Evoked Potentials (SSEPs) and Electroencephalography (EEG) when used in monitoring critically ill children

STP — Cardiac Science

The sensitivity and specificity of dobutamine stress echocardiography: a single centre, retrospective service evaluation

STP — Clinical Microbiology

Towards the National Gram Negative Bloodstream Infection Reduction Objectives: Identification of Risk Factors in the Acute Setting to Inform Reduction Strategies

STP — Cardiac Science

Trans-mitral Doppler in differentiating between supraventricular and ventricular tachycardia.

STP — Image Ionising Radiation

Using list-mode gating to estimate the noise in PET: A comparison of Q.Clear and OSEM

STP — Genetics

Validating the Sapientia inheritance filters to facilitate implementing trio clinical exome sequencing into diagnostic service

STP — Clinical Biochemistry

Validation and method comparison of carboxyhaemoglobin by headspace-gas chromatography-thermal conductivity detector (HS-GC-TCD)

STP — Clinical Bioinformatics - Genomics

VASA: An ACMG Variant Scoring Assistant for Sequence Variant Classification, Variant Review and Teaching

STP — Radiotherapy Physics

Verification and implementation of an electron Monte Carlo algorithm for electron treatment planning.

STP — Image Ionising Radiation

Verification of the Accuracy of Image-Based Dosimetry Methods used in SIRT Microsphere Therapy

STP — Haematology and Transfusion Science

Verification of the Active-B12 assay on the Abbott Architect