Radioguided Surgery using Technetium99mTc-HYNIC-Tyr3-Octreotide (Tektrotyd) for Gastro-Entero-Pancreatic Neuroendocrine Tumours (GEP-NETS)

Abstract

With respect to 99mTc-Tektrotyd for localisation of GEP-NETS:

  1. Identify the optimal imaging parameters and image reconstruction techniques for peak target-to-background ratio on images of phantoms and on sequential images of patients to identify optimum time points
  2. Identify the most accurate image quantification parameters for target and normal tissue uptake values
  3. Small scale comparison of the number of tumours identified on pre-operative imaging, during the procedure using surgical palpation and/or using an interoperative gamma-probe
  4. Quantification of radiation doses received by theatre staff during RGS
  5. Validation of the image quantification using pre-surgical imaging and ex-vivo samples