Research project

Quantification of Lu-177 on a Cadnium Zinc Telluride Gamma Camera

Imaging (Ionising Radiation)
Project published
Anna Chilcott
Training location
Royal Surrey County Hospital, Guildford

Solid state gamma cameras with Cadmium Zinc Telluride (CZT) detectors provide improved spectral resolution and improved count-rate performance compared to conventional scintillation cameras. This project will explore how these differences influence the accuracy of Lu-177 quantification in post-therapy patient imaging. Monte Carlo methods will be used to model the CZT detector and appropriate sources of Lu-177. The model will be validated against experimental data acquired on a CZT camera. Experimental work on the CZT camera will include basic camera characterisation using sources of Lu-177, according to the NEMA specifications. Phantom studies designed to simulate realistic patient scatter conditions will be conducted. Analysis will be used to determine optimal acquisition and post-processing parameters. The optimised imaging parameters and sensitivity factor calculated will be implemented for patient imaging, in order to calculate the activity within regions of Lu-177 uptake. 10 patients will have quantification carried out on their Lu-177 DOTATATE post-therapy SPECT/CT to calculate the activity within target lesions and organs at risk across their 4 treatment cycles, so that lesion doses can be calculated. Improved quantification accuracy of Lu-177 imaging will allow improved accuracy of dosimetry for Lu-177 DOTATATE and Lu-177 PSMA therapies. This will allow a potential for personalised Lu-177 DOTATATE and PSMA activity prescriptions giving the patient a better chance of the treatment working for them.


None – only just started.

Last updated on 2nd March 2023